Drug response

Our offer includes 8 panels containing genes, disorders of which can be linked to drug metabolism. Disease diagnostics, based on the highest-quality genetic test using the next-generation sequencing method, enables appropriate therapy for the patient.

The analysis of the patient's response to medications allows us to determine his type of metabolism. Whether it metabolizes the drug within a standard time, whether it has a shortened or extended metabolism time, or does not metabolize the drug completely. Determining whether a given drug is metabolized effectively by the patient requires an analysis of gene polymorphisms related to drug metabolism. The analysis of the response to drugs is of great importance before starting, for example, chemotherapy or cardiac therapy.

Cytochrome P450 enzymes play a major role in drug metabolism. More than 50 enzymes from this group have been identified, but only 6 of them are responsible for 90% of metabolized drugs. The information obtained from the drug response study is extremely important even in everyday life, as approximately 10% of the population should not use ibuporfen, and naproxen may alternatively use it. Also in people with slow metabolism of morphine derivatives or in people completely not metabolizing opioid drugs (up to 20% of the Caucasian population), analgesics from a different group should be considered due to the lack of therapeutic effect.

All genetic tests are performed using the next-generation sequencing method, using Illumina sequencers. Our tests are subject to internal and external control. The laboratory is subject to continuous external quality control.